This issue of Anesthesiology Clinics focuses on Quality Improvement and Implementation Science, with topics including: Applying implementation science principles to perioperative care; Emergency checklists in perioperative care; Human factors applied to perioperative process improvement; Handoffs in perioperative care; Use of simulation in performance improvement; Developing capacity to do improvement science work; Developing multicenter registries to advance quality science; Rethinking clinical workflow; data-driven quality improvement; and Scaling quality improvement at the health system level.